236 Carboxymethyl cellulose (CMC)-based transdermal delivery of insulin

Several chemophysical methods that facilitates the transport of bioactive macromolecules, including insulin, across skin barrier have been reported. These include use transdermal photopolymerization and electroporation, microneedles ultrasound-mediated penetration. Delivery enabling insulin without auxiliary physical penetration for passive delivery also attracted a great deal attention. We recently designed synthesized novel biocompatible nanocarriers based on modified polysaccharides. The N-Alkylamidated carboxymethyl cellulose (CMC) derivatives were characterized using attenuated total reflectance fourier transform infrared (ATR-FTIR) nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography thermogravimetric, calorimetric microscopic techniques. Two derivatives, CMC-6 CMC-12, able to enhancement delivery, showing remarkable 85% permeation, evaluated in Franz cell apparatus used with human skin. Finally, toxicity studies revealed no alteration epidermal viability upon treatment absence any irritation or amplified cytokine release, verifying safety prepared carriers. presented carriers potential become biocompatible, safe feasible platform design effective systems macromolecules medicine cosmetics. In addition, reduces pain infection risk comparison injections, which may increase compliance glycemic control diabetic patients.